MEGF6

Across TCGA cell cohorts, MEGF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,923 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MEGF6-associated GO terms across cancer lineages are Negative regulation of protein-containing complex assembly, Protein localization to plasma membrane, and Plasma membrane organization. Each is linked with MEGF6 in more than 11 cancer types. Because this analysis shows association rather than direction, both MEGF6-to-partner and partner-to-MEGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex assembly grouped by MEGF6-low versus MEGF6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF6→partner) and Y-score (partner→MEGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of protein-containing complex assembly →	+0.069	+1.772	<.001	<.001	3	12
OESOPHAGUS	Protein localization to plasma membrane →	+0.094	+3.052	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Plasma membrane organization →	+0.094	+2.597	.002	.002	3	11
LUNG_NSCLC_LUSC	Actin filament organization →	+0.114	+2.578	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.112	+2.177	<.001	<.001	3	10
OVARY	Regulation of protein localization to cell periphery →	+0.108	+1.947	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,923 associations by consensus.

Negative regulation of protein-containing complex assembly by MEGF6 expression — OESOPHAGUS

Explore this box plot interactively →