MEGF6

Across TCGA cell cohorts, MEGF6 mutation is significantly associated with the RNA expression of many other genes, with 976 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEGF6-associated genes across cancer lineages are OR1L6, STH, and TTLL2. Each is linked with MEGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF6-to-partner and partner-to-MEGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by MEGF6-low versus MEGF6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF6→partner) and Y-score (partner→MEGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	2
OVARY	STH →	+0.069	+2.643	.003	.009	3	2
CNS	TTLL2 →	+0.174	+3.736	<.001	.009	3	2
LUNG_SCLC	TCP10L3 →	+0.169	+3.071	<.001	.004	3	2
LARGE_INTESTINE	ST13 →	+0.440	+2.364	.003	<.001	3	2
LARGE_INTESTINE	CDKL1 →	+0.750	+2.339	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 976 associations by consensus.

OR1L6 by MEGF6 expression — BONE

Explore this box plot interactively →