MEGF10

Across TCGA patient cohorts, MEGF10 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEGF10-associated genes across cancer lineages are FoxM1, FASN, and p38-MAPK_pT180_Y182. Each is linked with MEGF10 in more than 3 cancer types. Because this analysis shows association rather than direction, both MEGF10-to-partner and partner-to-MEGF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MEGF10-low versus MEGF10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF10→partner) and Y-score (partner→MEGF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.272	+2.247	<.001	.001	3	4
STAD	FASN →	+0.638	+2.823	.005	.034	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.281	-1.502	.027	.028	3	3
SKCM	Caveolin-1 →	-0.502	-1.807	.027	.024	3	3
UCEC	C-Raf →	+0.114	+1.000	.002	.037	3	3
SKCM	Cyclin-B1 →	+0.625	+2.321	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

FoxM1 by MEGF10 expression — SKCM

Explore this box plot interactively →