MEGF10

Across TCGA cell cohorts, MEGF10 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEGF10-associated genes across cancer lineages are PHOX2B, TP53TG3E, and AGXT2. Each is linked with MEGF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF10-to-partner and partner-to-MEGF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by MEGF10-low versus MEGF10-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF10→partner) and Y-score (partner→MEGF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PHOX2B →	+0.011	+3.906	<.001	.009	3	2
LUNG_NSCLC_LUAD	TP53TG3E →	+0.168	+3.362	.001	.007	3	2
OVARY	AGXT2 →	+0.023	+4.228	.001	.006	3	1
OVARY	ADAMDEC1 →	+0.031	+4.450	<.001	.004	3	1
OVARY	OR4F15 →	+0.018	+4.029	<.001	.009	3	1
LUNG_SCLC	LYZL2 →	+0.026	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

PHOX2B by MEGF10 expression — BLOOD_Myeloma

Explore this box plot interactively →