Across TCGA pan-cancer cohorts, MEG3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated MEG3 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MEG3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MEG3 expression acts as an unfavorable survival marker.

COAD are the cancer types where MEG3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.111	0.871	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: MEG3 tumor-vs-normal RNA expression · all MEG3 data types