MEFV

Across TCGA patient cohorts, MEFV mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEFV-associated genes across cancer lineages are c-Met_pY1235, p62 Lck ligand, and IRS1. Each is linked with MEFV in more than 2 cancer types. Because this analysis shows association rather than direction, both MEFV-to-partner and partner-to-MEFV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by MEFV-low versus MEFV-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEFV→partner) and Y-score (partner→MEFV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Met_pY1235 →	+0.133	+3.000	.015	.036	3	3
UCEC	p62 Lck ligand →	+0.319	+2.999	.001	<.001	3	3
SKCM	IRS1 →	+0.148	+1.415	.003	.041	3	3
SKCM	PDCD4 →	-0.324	-1.807	.016	.024	3	3
UCEC	JNK_pT183_Y185 →	-0.165	-2.115	.001	.016	3	2
COAD	14-3-3_beta →	-0.156	-2.961	.046	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

c-Met_pY1235 by MEFV expression — LUAD

Explore this box plot interactively →