MEFV

Across TCGA cell cohorts, MEFV mutation is significantly associated with the RNA expression of many other genes, with 772 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEFV-associated genes across cancer lineages are LINGO4, TGM7, and KRTAP20-2. Each is linked with MEFV in more than 1 cancer types. Because this analysis shows association rather than direction, both MEFV-to-partner and partner-to-MEFV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINGO4 grouped by MEFV-low versus MEFV-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEFV→partner) and Y-score (partner→MEFV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LINGO4 →	+0.113	+2.769	<.001	.001	3	2
SOFT_TISSUE	TGM7 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP20-2 →	+0.122	+5.369	<.001	.004	3	1
BLOOD_Leukemia	MYL7 →	+0.047	+3.339	.007	.006	3	1
BLOOD_Leukemia	C20orf85 →	+0.027	+3.969	<.001	.009	3	1
BLOOD_Leukemia	SCN7A →	+0.740	+3.769	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 772 associations by consensus.

LINGO4 by MEFV expression — LARGE_INTESTINE

Explore this box plot interactively →