MEFV

Across TCGA cell cohorts, MEFV mutation is significantly associated with the mutation status of many other genes, with 6,255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEFV-associated genes across cancer lineages are DGKI, CACNA1F, and ATR. Each is linked with MEFV in more than 4 cancer types. Because this analysis shows association rather than direction, both MEFV-to-partner and partner-to-MEFV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGKI grouped by MEFV-low versus MEFV-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEFV→partner) and Y-score (partner→MEFV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DGKI →	+4.066	+5.022	.001	.001	1	5
LUNG_NSCLC_LUAD	CACNA1F →	+3.266	+2.981	.009	.009	1	5
LARGE_INTESTINE	ATR →	+2.471	+3.754	<.001	<.001	1	5
SOFT_TISSUE	CHRM3 →	+5.066	+4.502	.007	.007	1	4
SOFT_TISSUE	IQGAP2 →	+5.066	+4.502	.007	.007	1	4
SOFT_TISSUE	PEG3 →	+3.066	+4.369	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,255 associations by consensus.

DGKI by MEFV expression — SOFT_TISSUE

Explore this box plot interactively →