MEF2C-AS1

Across TCGA pan-cancer cohorts, MEF2C-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MEF2C-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MEF2C-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MEF2C-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, KIRP, and UVM are the cancer types where MEF2C-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.448	0.245	<.001	83	view →
KIRP	OS	Quartile	All	0.869	0.977	<.001	51	view →
UVM	DFS	Tertile	All	0.863	0.393	<.001	43	view →
BLCA	OS	Tertile	II,III,IV	0.528	0.670	.004	39	view →
BRCA	OS	Median	II,III,IV	0.596	0.517	.005	39	view →
UCS	DFS	Median	III,IV	0.517	0.156	.007	38	view →
LUAD	OS	Tertile	All	0.794	0.572	.001	25	view →
ACC	DFS	Median	III,IV	0.844	0.298	.011	25	view →
ESCA	DFS	Quartile	III,IV	0.723	0.288	.006	23	view →
READ	DFS	Quartile	III,IV	0.517	0.902	.002	16	view →
KIRC	DFS	Quartile	All	0.897	0.718	.008	15	view →
CESC	OS	Median	All	0.923	0.833	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MEF2C-AS1–HNSC (DFS)

Open the HNSC breakdown →