Across TCGA patient cohorts, MEF2B mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEF2B-associated genes across cancer lineages are eIF4E, MEK1, and Mre11. Each is linked with MEF2B in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2B-to-partner and partner-to-MEF2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2B→partner) and Y-score (partner→MEF2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+3.584	.030	.002	3	2
UCEC	MEK1 →	+0.503	+3.321	.004	.010	3	1
UCEC	Mre11 →	+0.089	+3.029	.031	.018	3	1
UCEC	MSH2 →	-0.435	-2.459	<.001	.020	3	1
UCEC	MSH6 →	-0.625	-2.321	<.001	.033	3	1
UCEC	p62 Lck ligand →	+0.444	+3.179	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

MEF2B survival (RNA) · tumor vs normal (RNA) · all MEF2B data types