Across TCGA cell cohorts, MEF2B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MEF2B-associated genes across cancer lineages are OR9K2, LGALS13, and OR14C36. Each is linked with MEF2B in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2B-to-partner and partner-to-MEF2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2B→partner) and Y-score (partner→MEF2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9K2 →	+0.014	+4.662	<.001	.003	3	1
CNS	LGALS13 →	+0.115	+4.981	<.001	.008	3	1
CNS	OR14C36 →	+0.021	+5.754	.007	.002	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
LARGE_INTESTINE	C6orf118 →	+0.186	+3.793	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR2F2 →	+0.027	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MEF2B survival (RNA) · tumor vs normal (RNA) · all MEF2B data types