MED8

Across TCGA patient cohorts, MED8 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED8-associated genes across cancer lineages are RNA5SP407, PUDPP1, and MAP2K1. Each is linked with MED8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED8-to-partner and partner-to-MED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by MED8-low versus MED8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED8→partner) and Y-score (partner→MED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP407 →	+0.633	+7.924	<.001	.008	3	2
SKCM	PUDPP1 →	+0.135	+5.970	<.001	.002	3	1
UCEC	MAP2K1 →	+0.674	+3.202	.004	.009	3	1
UCEC	AQP7P4 →	+0.076	+3.805	<.001	.002	3	1
UCEC	OR4M1 →	+0.048	+3.657	.003	<.001	3	1
UCEC	NANOGP1 →	+0.283	+3.518	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

RNA5SP407 by MED8 expression — LUSC

Explore this box plot interactively →