MED7

Across TCGA patient cohorts, MED7 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED7-associated genes across cancer lineages are Notch1, p62 Lck ligand, and PDK1_pS241. Each is linked with MED7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED7-to-partner and partner-to-MED7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MED7-low versus MED7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED7→partner) and Y-score (partner→MED7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.168	+2.820	.023	.035	3	1
UCEC	p62 Lck ligand →	+0.426	+3.321	.012	.010	3	1
UCEC	PDK1_pS241 →	+0.190	+2.183	.034	.035	3	1
UCEC	Annexin-1 →	+0.644	+2.827	.019	.035	3	1
UCEC	STAT3_pY705 →	-0.535	-2.999	<.001	.035	3	1
UCEC	Caspase-8 →	-0.261	-2.973	.048	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Notch1 by MED7 expression — UCEC

Explore this box plot interactively →