Across TCGA pan-cancer cohorts, MED6P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MED6P1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MED6P1 RNA is repressed in tumor relative to normal tissue. In most cancer types MED6P1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where MED6P1 tumor–normal differential expression is most reproducible.