MED4

Across TCGA patient cohorts, MED4 protein abundance is significantly associated with the protein abundance of many other proteins, with 28,737 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MED4-associated proteins across cancer lineages are SUGP1, MED10, and RNF20. Each is linked with MED4 in more than 8 cancer types. Because this analysis shows association rather than direction, both MED4-to-partner and partner-to-MED4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MED4 versus SUGP1 in LSCC, with a Pearson correlation of 0.69.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MED4→partner) and Y-score (partner→MED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUGP1 →	+0.212	+0.264	<.001	<.001	3	9
LSCC	MED10 →	+0.303	+0.232	<.001	<.001	3	9
GBM	RNF20 →	+0.324	+0.241	<.001	<.001	3	8
OV	RPRD2 →	+0.349	+0.321	<.001	<.001	3	8
GBM	SART1 →	+0.359	+0.291	<.001	<.001	3	8
GBM	SF3B2 →	+0.203	+0.176	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,737 associations by consensus.

MED4 vs SUGP1 — LSCC

Explore this scatter interactively →