MED28

Across TCGA pan-cancer cohorts, MED28 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MED28’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MED28 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED28 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where MED28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.504	<.001	10	view →
LIHC	Female	II,III,IV	+0.934	<.001	9	view →
COAD	All	II,III,IV	+0.382	<.001	6	view →
CHOL	Female	All	+1.760	<.001	5	view →
LUAD	Female	III,IV	−0.514	.001	2	view →
LUAD	All	IV	+0.394	.045	2	view →
UCEC	All	All	−0.363	.036	2	view →
BRCA	Female	All	−0.152	.020	2	view →
KICH	All	All	−0.318	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

MED28–HNSC

Open the HNSC breakdown →