MED26

Across TCGA patient cohorts, MED26 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED26-associated genes across cancer lineages are MEK1, Annexin-1, and 4E-BP1. Each is linked with MED26 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED26-to-partner and partner-to-MED26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MED26-low versus MED26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED26→partner) and Y-score (partner→MED26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.448	+2.584	.001	.001	3	2
UCEC	Annexin-1 →	+0.720	+2.584	<.001	.010	3	2
UCEC	4E-BP1 →	+0.341	+2.459	.001	.018	3	2
UCEC	14-3-3_beta →	-0.084	-3.143	.028	.018	3	1
UCEC	eEF2 →	+0.443	+2.584	.001	.001	3	1
UCEC	ERK2 →	+0.211	+3.321	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by MED26 expression — UCEC

Explore this box plot interactively →