MED24

Across TCGA patient cohorts, MED24 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED24-associated genes across cancer lineages are PREX1, A-Raf_pS299, and p62 Lck ligand. Each is linked with MED24 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED24-to-partner and partner-to-MED24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by MED24-low versus MED24-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED24→partner) and Y-score (partner→MED24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PREX1 →	+0.308	+2.820	.002	.035	3	2
UCEC	A-Raf_pS299 →	-0.110	-1.678	.002	.019	3	2
UCEC	p62 Lck ligand →	+0.339	+1.530	<.001	.004	3	2
UCEC	PCNA →	+0.197	+1.716	.002	.003	3	2
UCEC	STAT3_pY705 →	-0.332	-1.874	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.546	+2.169	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PREX1 by MED24 expression — COAD

Explore this box plot interactively →