MED24

Across TCGA cell cohorts, MED24 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED24-associated genes across cancer lineages are UTF1, IQCF5, and USP17L22. Each is linked with MED24 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED24-to-partner and partner-to-MED24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by MED24-low versus MED24-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED24→partner) and Y-score (partner→MED24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.010	+4.357	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

UTF1 by MED24 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →