MED23

Across TCGA patient cohorts, MED23 mutation is significantly associated with the RNA expression of many other genes, with 2,992 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED23-associated genes across cancer lineages are CCL4, CCL3, and TAOK2. Each is linked with MED23 in more than 3 cancer types. Because this analysis shows association rather than direction, both MED23-to-partner and partner-to-MED23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by MED23-low versus MED23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED23→partner) and Y-score (partner→MED23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+0.787	+2.150	<.001	<.001	3	4
UCEC	CCL3 →	+0.561	+1.401	.001	.002	3	4
UCEC	TAOK2 →	+0.259	+1.776	.001	.007	3	3
UCEC	GEMIN4 →	+0.321	+1.869	.007	.004	3	3
UCEC	PRF1 →	+0.873	+1.743	<.001	<.001	3	3
UCEC	MRPL54 →	+0.313	+1.858	.007	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,992 associations by consensus.

CCL4 by MED23 expression — UCEC

Explore this box plot interactively →