MED23

Across TCGA patient cohorts, MED23 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED23-associated genes across cancer lineages are eIF4E, MEK1, and Shc_pY317. Each is linked with MED23 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED23-to-partner and partner-to-MED23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MED23-low versus MED23-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED23→partner) and Y-score (partner→MED23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.183	+2.820	.037	.035	3	2
UCEC	MEK1 →	+0.439	+2.321	<.001	<.001	3	2
COAD	Shc_pY317 →	-0.230	-3.161	.005	.019	2	3
COAD	TSC1 →	-0.458	-3.169	<.001	.018	3	2
UCEC	ATM →	-0.620	-1.807	<.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.419	+3.178	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eIF4E by MED23 expression — COAD

Explore this box plot interactively →