MED22

Across TCGA patient cohorts, MED22 protein abundance is significantly associated with the RNA expression of many other genes, with 13,270 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MED22-associated genes across cancer lineages are NUF2, EME1, and PRMT5. Each is linked with MED22 in more than 5 cancer types. Because this analysis shows association rather than direction, both MED22-to-partner and partner-to-MED22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MED22 versus NUF2 in LUAD, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED22→partner) and Y-score (partner→MED22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUF2 →	+1.275	+0.187	<.001	<.001	3	6
UCEC	EME1 →	+0.821	+0.212	<.001	<.001	3	6
LSCC	PRMT5 →	+0.816	+0.378	<.001	<.001	3	5
UCEC	NCAPD2 →	+0.822	+0.241	<.001	<.001	3	5
LSCC	NSD2 →	+0.653	+0.250	<.001	<.001	3	5
LSCC	EXOSC2 →	+0.708	+0.277	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,270 associations by consensus.

MED22 vs NUF2 — LUAD

Explore this scatter interactively →