MED22

Across TCGA patient cohorts, MED22 mutation is significantly associated with the RNA expression of many other genes, with 1,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED22-associated genes across cancer lineages are MIR599, RN7SKP224, and RNU6-1305P. Each is linked with MED22 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED22-to-partner and partner-to-MED22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR599 grouped by MED22-low versus MED22-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED22→partner) and Y-score (partner→MED22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR599 →	+1.138	+4.418	<.001	.008	3	3
COAD	RN7SKP224 →	+0.299	+5.332	.003	.002	3	2
COAD	RNU6-1305P →	+0.677	+4.537	<.001	.006	3	2
COAD	RNU6-979P →	+0.669	+4.868	<.001	<.001	3	2
COAD	RNU6-601P →	+0.672	+4.666	<.001	.005	3	2
COAD	RNU6-1093P →	+0.597	+4.542	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,120 associations by consensus.

MIR599 by MED22 expression — COAD

Explore this box plot interactively →