MED22

Across TCGA patient cohorts, MED22 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED22-associated genes across cancer lineages are FOXO3a_pS318_S321, GSK-3_pS9, and Ku80. Each is linked with MED22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED22-to-partner and partner-to-MED22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by MED22-low versus MED22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED22→partner) and Y-score (partner→MED22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.139	-2.321	.027	.035	3	1
UCEC	GSK-3_pS9 →	-0.480	-2.999	.018	.035	3	1
UCEC	Ku80 →	+0.258	+2.820	.029	.035	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.321	.031	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.669	-2.308	.003	.036	3	1
UCEC	PKC-a →	+0.419	+2.820	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FOXO3a_pS318_S321 by MED22 expression — UCEC

Explore this box plot interactively →