MED22

Across TCGA cell cohorts, MED22 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED22-associated genes across cancer lineages are LGI1, C1QL2, and NKX2-6. Each is linked with MED22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED22-to-partner and partner-to-MED22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by MED22-low versus MED22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED22→partner) and Y-score (partner→MED22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LGI1 by MED22 expression — BLOOD_Leukemia

Explore this box plot interactively →