MED21

Across TCGA pan-cancer cohorts, MED21 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MED21 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MED21 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MED21 expression acts as an unfavorable survival marker.

BLCA and UCEC are the cancer types where MED21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.158	0.720	<.001	48	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MED21–BLCA (OS)

Open the BLCA breakdown →