MED21

Across TCGA patient cohorts, MED21 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED21-associated genes across cancer lineages are MIR98, MIR7702, and MIR8055. Each is linked with MED21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED21-to-partner and partner-to-MED21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR98 grouped by MED21-low versus MED21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED21→partner) and Y-score (partner→MED21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR98 →	+0.446	+3.386	<.001	.008	3	1
UCEC	MIR7702 →	+0.537	+5.738	<.001	<.001	3	1
UCEC	MIR8055 →	+1.015	+3.643	<.001	.008	3	1
UCEC	MIR5696 →	+0.520	+4.708	<.001	<.001	3	1
UCEC	FTLP5 →	+0.366	+3.598	<.001	.009	3	1
COAD	ATP5PBP4 →	+0.098	+7.409	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MIR98 by MED21 expression — UCEC

Explore this box plot interactively →