MED20

Across TCGA patient cohorts, MED20 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED20-associated genes across cancer lineages are mTOR_pS2448, p70-S6K_pT389, and Rictor_pT1135. Each is linked with MED20 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED20-to-partner and partner-to-MED20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MED20-low versus MED20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED20→partner) and Y-score (partner→MED20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.172	-3.150	.016	.019	3	1
UCEC	p70-S6K_pT389 →	-0.213	-2.999	.020	.035	3	1
UCEC	Rictor_pT1135 →	-0.113	-3.000	.022	.036	3	1
UCEC	Shc_pY317 →	-0.154	-2.459	.036	.020	3	1
UCEC	STAT3_pY705 →	-0.485	-2.459	<.001	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.622	+3.019	.030	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by MED20 expression — UCEC

Explore this box plot interactively →