MED17

Across TCGA patient cohorts, MED17 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED17-associated genes across cancer lineages are ERK2, Ku80, and MEK1. Each is linked with MED17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED17-to-partner and partner-to-MED17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MED17-low versus MED17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED17→partner) and Y-score (partner→MED17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.211	+2.087	.001	.005	3	1
UCEC	Ku80 →	+0.206	+1.453	.012	.015	3	1
UCEC	MEK1 →	+0.333	+1.807	.008	.025	3	1
UCEC	MSH2 →	-0.218	-1.781	.006	.024	3	1
UCEC	Notch1 →	+0.170	+2.009	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.282	+3.009	.012	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ERK2 by MED17 expression — UCEC

Explore this box plot interactively →