MED16

Across TCGA patient cohorts, MED16 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED16-associated genes across cancer lineages are ATM, Rad50, and 4E-BP1. Each is linked with MED16 in more than 4 cancer types. Because this analysis shows association rather than direction, both MED16-to-partner and partner-to-MED16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MED16-low versus MED16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED16→partner) and Y-score (partner→MED16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.524	-2.986	.008	.035	3	5
UCEC	Rad50 →	-0.280	-3.156	.008	.018	3	2
UCEC	4E-BP1 →	+0.269	+2.199	.022	.033	3	2
STAD	Fibronectin →	+0.379	+3.190	.024	.009	3	1
STAD	Myosin-IIa_pS1943 →	+0.516	+3.000	.049	.034	3	1
STAD	c-Kit →	-0.446	-3.000	.004	.034	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by MED16 expression — UCEC

Explore this box plot interactively →