MED16

Across TCGA cell cohorts, MED16 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED16-associated genes across cancer lineages are ZSCAN1, DYDC1, and TBL1Y. Each is linked with MED16 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED16-to-partner and partner-to-MED16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by MED16-low versus MED16-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED16→partner) and Y-score (partner→MED16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	DYDC1 →	+0.236	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LIVER	RBMY1F →	+0.437	+3.977	<.001	.006	3	1
LIVER	OTOL1 →	+0.017	+3.977	<.001	.006	3	1
LIVER	CYP2A13 →	+0.007	+3.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ZSCAN1 by MED16 expression — PANCREAS

Explore this box plot interactively →