MED13L

Across TCGA patient cohorts, MED13L mutation is significantly associated with the RNA expression of many other genes, with 3,488 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED13L-associated genes across cancer lineages are CENPH, PHF5A, and MND1. Each is linked with MED13L in more than 3 cancer types. Because this analysis shows association rather than direction, both MED13L-to-partner and partner-to-MED13L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPH grouped by MED13L-low versus MED13L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13L→partner) and Y-score (partner→MED13L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPH →	+0.328	+1.074	.003	.001	3	4
UCEC	PHF5A →	+0.265	+1.366	.002	<.001	3	4
UCEC	MND1 →	+0.428	+1.064	.001	.002	3	4
COAD	PSMC3IP →	+0.398	+2.615	.005	.005	3	4
PRAD	NIFKP2 →	+0.065	+5.433	<.001	<.001	3	3
UCEC	TAF9 →	+0.431	+1.649	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,488 associations by consensus.

CENPH by MED13L expression — UCEC

Explore this box plot interactively →