MED13L

Across TCGA patient cohorts, MED13L mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED13L-associated genes across cancer lineages are YAP_pS127, p27_pT157, and p62 Lck ligand. Each is linked with MED13L in more than 3 cancer types. Because this analysis shows association rather than direction, both MED13L-to-partner and partner-to-MED13L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP_pS127 grouped by MED13L-low versus MED13L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13L→partner) and Y-score (partner→MED13L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	YAP_pS127 →	-0.426	-2.999	.017	.035	3	3
SKCM	p27_pT157 →	+0.187	+2.246	<.001	.030	2	4
UCEC	p62 Lck ligand →	+0.266	+1.321	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.184	+1.078	.005	.006	3	3
COAD	4E-BP1_pT70 →	+0.096	+1.593	.040	.043	3	3
LUAD	CDK1 →	+0.245	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

YAP_pS127 by MED13L expression — BLCA

Explore this box plot interactively →