MED13L

Across TCGA cell cohorts, MED13L mutation is significantly associated with the RNA expression of many other genes, with 742 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED13L-associated genes across cancer lineages are RXFP2, OPN1MW2, and CFAP36. Each is linked with MED13L in more than 1 cancer types. Because this analysis shows association rather than direction, both MED13L-to-partner and partner-to-MED13L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RXFP2 grouped by MED13L-low versus MED13L-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13L→partner) and Y-score (partner→MED13L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RXFP2 →	+0.252	+4.044	<.001	.009	3	2
LUNG_SCLC	OPN1MW2 →	+0.477	+4.643	<.001	.004	3	2
LARGE_INTESTINE	CFAP36 →	+0.632	+2.829	<.001	<.001	3	2
BLOOD_Leukemia	CFHR2 →	+0.104	+2.954	<.001	.005	3	2
LARGE_INTESTINE	C12orf57 →	+0.826	+2.043	<.001	.008	3	2
LARGE_INTESTINE	TLCD4 →	+0.830	+3.936	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

RXFP2 by MED13L expression — LUNG_SCLC

Explore this box plot interactively →