MED11

Across TCGA patient cohorts, MED11 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MED11-associated genes across cancer lineages are BNIP3P2, RNU6-13P, and MIR4306. Each is linked with MED11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED11-to-partner and partner-to-MED11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P2 grouped by MED11-low versus MED11-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED11→partner) and Y-score (partner→MED11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	BNIP3P2 →	+0.095	+6.837	<.001	<.001	3	2
UCEC	RNU6-13P →	+0.593	+3.969	<.001	.005	3	2
HNSC	MIR4306 →	+0.349	+4.822	<.001	.006	3	2
COAD	OR4X2 →	+0.054	+7.741	<.001	.009	3	2
CESC	POTEH-AS1 →	+0.018	+5.669	.003	.003	3	1
CESC	RPL12P22 →	+0.111	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

BNIP3P2 by MED11 expression — CESC

Explore this box plot interactively →