MED1

Across TCGA patient cohorts, MED1 mutation is significantly associated with the RNA expression of many other genes, with 3,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED1-associated genes across cancer lineages are XPNPEP1, PPIL4, and GTF2B. Each is linked with MED1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED1-to-partner and partner-to-MED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XPNPEP1 grouped by MED1-low versus MED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED1→partner) and Y-score (partner→MED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XPNPEP1 →	+0.392	+3.095	.002	<.001	3	3
UCEC	PPIL4 →	+0.573	+2.212	<.001	<.001	3	3
UCEC	GTF2B →	+0.452	+2.255	<.001	<.001	3	3
UCEC	MFSD14C →	+0.671	+3.119	<.001	<.001	3	3
BLCA	TRGJP2 →	+0.354	+2.073	.008	.006	3	3
UCEC	UBE2L3 →	+0.320	+3.815	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,813 associations by consensus.

XPNPEP1 by MED1 expression — UCEC

Explore this box plot interactively →