MED1

Across TCGA patient cohorts, MED1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED1-associated genes across cancer lineages are Bap1-c-4, EGFR_pY1068, and ATM. Each is linked with MED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED1-to-partner and partner-to-MED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bap1-c-4 grouped by MED1-low versus MED1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED1→partner) and Y-score (partner→MED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Bap1-c-4 →	-0.338	-2.321	.034	.031	3	2
CESC	EGFR_pY1068 →	-0.349	-2.321	.033	.031	3	2
UCEC	ATM →	-0.562	-2.321	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.922	+3.107	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.261	-4.060	.003	<.001	3	2
CESC	ERCC1 →	-0.316	-2.321	.001	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Bap1-c-4 by MED1 expression — CESC

Explore this box plot interactively →