MED1

Across TCGA cell cohorts, MED1 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED1-associated genes across cancer lineages are SLC7A14, PRKAA2, and BTC. Each is linked with MED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED1-to-partner and partner-to-MED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A14 grouped by MED1-low versus MED1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED1→partner) and Y-score (partner→MED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC7A14 →	+0.517	+2.874	<.001	.009	3	2
BLOOD_Lymphoma	PRKAA2 →	+0.622	+3.392	.001	.002	3	2
BLOOD_Lymphoma	BTC →	+0.057	+2.956	<.001	.008	3	2
LARGE_INTESTINE	FAXC →	+1.294	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	GMCL1 →	+0.440	+2.588	.007	.004	3	2
LARGE_INTESTINE	F11 →	+0.030	+2.204	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

SLC7A14 by MED1 expression — BLOOD_Lymphoma

Explore this box plot interactively →