MECR

Across TCGA pan-cancer cohorts, MECR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MECR data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MECR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MECR expression acts as an unfavorable survival marker, although some lineages such as OV and COAD show a favorable association.

CCRCC, PDAC, and OV are the cancer types where MECR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.640	0.959	.002	22	view →
PDAC	DFS	Quartile	III,IV	0.232	0.898	.004	20	view →
OV	DFS	Tertile	All	0.835	0.496	.024	16	view →
LSCC	DFS	Tertile	III,IV	0.440	0.938	.003	15	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.914	.033	12	view →
UCEC	OS	Quartile	II,III,IV	0.634	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MECR–CCRCC (DFS)

Open the CCRCC breakdown →