MECR

Across TCGA patient cohorts, MECR mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MECR-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MSH2. Each is linked with MECR in more than 1 cancer types. Because this analysis shows association rather than direction, both MECR-to-partner and partner-to-MECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MECR-low versus MECR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECR→partner) and Y-score (partner→MECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.341	-3.321	.004	.010	3	1
UCEC	JNK2 →	+0.320	+2.459	<.001	.020	3	1
UCEC	MSH2 →	-0.310	-2.973	.005	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.236	+2.472	.018	.011	3	1
UCEC	NF2 →	+0.311	+2.999	.002	.035	3	1
UCEC	Shc_pY317 →	-0.193	-3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by MECR expression — UCEC

Explore this box plot interactively →