MECR

Across TCGA cell cohorts, MECR mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MECR-associated genes across cancer lineages are CX-5461, TPCA-1, and Alisertib. Each is linked with MECR in more than 1 cancer types. Because this analysis shows association rather than direction, both MECR-to-partner and partner-to-MECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CX-5461 grouped by MECR-low versus MECR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECR→partner) and Y-score (partner→MECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CX-5461 →	+0.702	+2.652	.016	.045	3	1
LARGE_INTESTINE	TPCA-1 →	+0.482	+2.786	.044	.037	3	1
LARGE_INTESTINE	Alisertib →	+0.791	+2.646	.029	.047	2	1
LARGE_INTESTINE	MN-64 →	+0.372	+2.646	.012	.047	2	1
LARGE_INTESTINE	GSK3337463A →	+0.367	+2.649	.031	.046	1	1
LARGE_INTESTINE	GSK429286A →	+0.339	+2.652	.030	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CX-5461 by MECR expression — LARGE_INTESTINE

Explore this box plot interactively →