MECP2

Across TCGA patient cohorts, MECP2 protein abundance is significantly associated with the RNA expression of many other genes, with 20,194 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MECP2-associated genes across cancer lineages are CENPA, CDC20, and KIF14. Each is linked with MECP2 in more than 8 cancer types. Because this analysis shows association rather than direction, both MECP2-to-partner and partner-to-MECP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MECP2 versus CENPA in GBM, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECP2→partner) and Y-score (partner→MECP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CENPA →	-1.031	-0.356	<.001	<.001	3	9
BRCA	CDC20 →	-1.839	-0.418	<.001	<.001	3	9
GBM	KIF14 →	-0.945	-0.242	<.001	.006	3	9
GBM	KIF18A →	-1.093	-0.277	<.001	.008	3	9
UCEC	DLGAP5 →	-1.035	-0.471	.001	<.001	3	9
GBM	GINS2 →	-1.043	-0.321	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,194 associations by consensus.

MECP2 vs CENPA — GBM

Explore this scatter interactively →