MECP2

Across TCGA patient cohorts, MECP2 mutation is significantly associated with the RNA expression of many other genes, with 6,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MECP2-associated genes across cancer lineages are HBZP1, PGK1, and FDPS. Each is linked with MECP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MECP2-to-partner and partner-to-MECP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBZP1 grouped by MECP2-low versus MECP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECP2→partner) and Y-score (partner→MECP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HBZP1 →	+0.207	+5.412	<.001	.001	3	3
UCEC	PGK1 →	+0.728	+1.621	<.001	<.001	3	3
UCEC	FDPS →	+0.338	+1.439	.006	.005	3	3
BRCA	LINC02304 →	+0.072	+4.201	<.001	.007	3	2
CESC	RNA5SP325 →	+0.125	+4.252	<.001	.006	3	2
ESCA	PSMC6 →	+0.469	+3.278	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,003 associations by consensus.

HBZP1 by MECP2 expression — COAD

Explore this box plot interactively →