MECP2

Across TCGA cell cohorts, MECP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,333 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MECP2-associated GO terms across cancer lineages are Positive regulation of microtubule nucleation, Regulation of microtubule nucleation, and Phosphatidylinositol biosynthetic process. Each is linked with MECP2 in more than 18 cancer types. Because this analysis shows association rather than direction, both MECP2-to-partner and partner-to-MECP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of microtubule nucleation grouped by MECP2-low versus MECP2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MECP2→partner) and Y-score (partner→MECP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of microtubule nucleation →	+0.158	+0.956	<.001	<.001	3	19
BONE	Regulation of microtubule nucleation →	+0.105	+1.018	.004	.001	3	14
CNS	Phosphatidylinositol biosynthetic process →	+0.058	+0.717	<.001	<.001	3	14
LIVER	Axo-dendritic protein transport →	+0.218	+0.793	<.001	<.001	3	14
BONE	Positive regulation of microtubule polymerization or depolymerization →	+0.100	+0.899	<.001	<.001	3	14
OESOPHAGUS	Regulation of translation at synapse, modulating synaptic transmission →	+0.146	+0.853	.006	.007	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,333 associations by consensus.

Positive regulation of microtubule nucleation by MECP2 expression — LUNG_SCLC

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