MECP2

Across TCGA cell cohorts, MECP2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MECP2-associated genes across cancer lineages are FUT5, SH3GL2, and PTH2R. Each is linked with MECP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MECP2-to-partner and partner-to-MECP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FUT5 grouped by MECP2-low versus MECP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECP2→partner) and Y-score (partner→MECP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FUT5 →	+0.018	+2.657	.002	.007	3	2
LARGE_INTESTINE	SH3GL2 →	+1.531	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PTH2R →	+0.814	+2.716	<.001	.009	3	1
LARGE_INTESTINE	TKTL2 →	+0.040	+3.187	<.001	.006	3	1
LARGE_INTESTINE	CLPSL1 →	+0.098	+2.791	.001	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+4.252	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FUT5 by MECP2 expression — LARGE_INTESTINE

Explore this box plot interactively →