MECOM

Across TCGA patient cohorts, MECOM RNA expression is significantly associated with the protein abundance of many other proteins, with 17,946 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MECOM-associated proteins across cancer lineages are MECOM_S624, MECOM_S726, and IL33. Each is linked with MECOM in more than 6 cancer types. Because this analysis shows association rather than direction, both MECOM-to-partner and partner-to-MECOM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MECOM versus MECOM_S624 in LUAD, with a Pearson correlation of 0.83.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MECOM→partner) and Y-score (partner→MECOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MECOM_S624 →	+1.444	+1.500	<.001	<.001	3	7
LUAD	MECOM_S726 →	+1.204	+1.552	<.001	<.001	3	7
BRCA	IL33 →	+0.975	+0.987	<.001	<.001	3	5
PDAC	MECOM_S1064 →	+1.385	+1.308	<.001	<.001	3	5
LUAD	SELENBP1 →	+0.744	+1.192	<.001	<.001	3	5
CCRCC	SLC9A3R2 →	+0.467	+0.614	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,946 associations by consensus.

MECOM vs MECOM_S624 — LUAD

Explore this scatter interactively →