MECOM

Across TCGA patient cohorts, MECOM protein abundance is significantly associated with the RNA expression of many other genes, with 10,617 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MECOM-associated genes across cancer lineages are MECOM-AS1, GPD1L, and VSIG2. Each is linked with MECOM in more than 5 cancer types. Because this analysis shows association rather than direction, both MECOM-to-partner and partner-to-MECOM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MECOM versus MECOM-AS1 in LUAD, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECOM→partner) and Y-score (partner→MECOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MECOM-AS1 →	+1.638	+0.739	<.001	<.001	3	6
LUAD	GPD1L →	+0.821	+0.548	<.001	<.001	3	4
LUAD	VSIG2 →	+1.445	+0.492	<.001	<.001	3	4
UCEC	ANKRD65 →	+1.267	+0.386	.001	<.001	3	4
LUAD	RBPMS-AS1 →	+0.829	+0.534	<.001	<.001	3	4
LSCC	PIGR →	+1.896	+0.350	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,617 associations by consensus.

MECOM vs MECOM-AS1 — LUAD

Explore this scatter interactively →