MECOM

Across TCGA patient cohorts, MECOM protein abundance is significantly associated with the protein abundance of many other proteins, with 21,101 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MECOM-associated proteins across cancer lineages are MECOM_S726, MECOM_S740, and MECOM_S1064. Each is linked with MECOM in more than 5 cancer types. Because this analysis shows association rather than direction, both MECOM-to-partner and partner-to-MECOM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MECOM versus MECOM_S726 in LUAD, with a Pearson correlation of 0.93.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MECOM→partner) and Y-score (partner→MECOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MECOM_S726 →	+1.368	+0.955	<.001	<.001	3	6
LUAD	MECOM_S740 →	+1.217	+1.091	<.001	<.001	3	6
LUAD	MECOM_S1064 →	+1.330	+0.998	<.001	<.001	3	5
HNSC	MECOM_S624 →	+1.929	+1.390	<.001	.001	2	6
LUAD	MECOM_S550 →	+1.323	+0.711	<.001	<.001	3	4
LSCC	RPL22 →	-0.276	-0.421	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,101 associations by consensus.

MECOM vs MECOM_S726 — LUAD

Explore this scatter interactively →