MECOM

Across TCGA cell cohorts, MECOM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,435 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MECOM-associated GO terms across cancer lineages are Viral process, Receptor internalization, and Negative regulation of protein depolymerization. Each is linked with MECOM in more than 9 cancer types. Because this analysis shows association rather than direction, both MECOM-to-partner and partner-to-MECOM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral process grouped by MECOM-low versus MECOM-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MECOM→partner) and Y-score (partner→MECOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Viral process →	+0.090	+1.750	<.001	<.001	3	10
SOFT_TISSUE	Receptor internalization →	+0.112	+1.931	<.001	<.001	3	9
SOFT_TISSUE	Negative regulation of protein depolymerization →	+0.064	+1.458	.002	<.001	3	9
LIVER	Biological process involved in symbiotic interaction →	+0.104	+2.605	.002	.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of protein localization to cell periphery →	+0.098	+2.362	.001	.004	3	8
STOMACH	Regulation of antimicrobial humoral response →	+1.333	+2.295	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,435 associations by consensus.

Viral process by MECOM expression — SOFT_TISSUE

Explore this box plot interactively →