MECOM

Across TCGA cell cohorts, MECOM mutation is significantly associated with the RNA expression of many other genes, with 811 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MECOM-associated genes across cancer lineages are IFT27, SEPSECS, and C12orf57. Each is linked with MECOM in more than 1 cancer types. Because this analysis shows association rather than direction, both MECOM-to-partner and partner-to-MECOM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFT27 grouped by MECOM-low versus MECOM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MECOM→partner) and Y-score (partner→MECOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IFT27 →	+0.770	+3.459	.001	<.001	3	2
LARGE_INTESTINE	SEPSECS →	+0.683	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.624	+2.404	.009	.004	3	2
LARGE_INTESTINE	EFCC1 →	+0.502	+2.482	<.001	.003	3	2
LARGE_INTESTINE	GRK4 →	+0.438	+1.850	.009	.006	3	2
LARGE_INTESTINE	ASPHD2 →	+0.577	+2.364	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 811 associations by consensus.

IFT27 by MECOM expression — LARGE_INTESTINE

Explore this box plot interactively →